Disadvantages of Open Reduction Internal Fixation (ORIF) include potential infection at the surgical site, scarring, and nerve or blood vessel damage. Hardware irritation, such as screws or plates causing discomfort, is possible. In some cases, stiffness or reduced range of motion may occur. Additionally, the procedure involves surgical risks and requires anesthesia. Long-term issues like hardware removal or joint degeneration may also arise, necessitating careful consideration of the potential drawbacks.